Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 8/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | CHRNA4 | P43681 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.61 |
| ▸ | GABRP | O00591 | 1/20 | 0.61 |
| ▸ | GABRD | O14764 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | ALB | P02768 | 1/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Medazepam SCHEMBL29642025 | 1.00 | OPRK1 (1.00) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Medazepam SCHEMBL18472 | 1.00 | OPRK1 (1.00) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Medazepam SCHEMBL78352 | 0.99 | OPRK1 (0.97) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL14018729 | 0.92 | OPRK1 (0.84) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL9472878 | 0.86 | OPRK1 (0.76) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Medazepam SCHEMBL30366342 | 0.86 | OPRK1 (0.76) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL11680057 | 0.86 | OPRK1 (0.76) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL9472170 | 0.86 | OPRK1 (0.75) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL3235774 | 0.84 | OPRK1 (0.73) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL11683117 | 0.83 | OPRK1 (0.71) | OPRK1PDE4DNR1I2ADORA3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4087614-A | Optically active 1,4-benzodiazepines intermediates | KAJFEZ FRANJO | 1978-05-02 | — | — | US | disclosed |
| US-4045569-A | Optically active 1,4-benzodiazepines and process for use as a tranquilizer | KAJFEZ FRANJO | 1977-08-30 | — | — | US | disclosed |
| US-3998811-A | SEDATIVES, TRANQUILIZERS; AMIDATION, CYCLIZATION, HYDROLYSIS | CRC COMPAGNIA DI RECERCA CHIMICA S.A. (CH) | 1976-12-21 | — | — | US | disclosed |