Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 12/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.44 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7627157 | 1.00 | S1PR1 (0.51) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL18140210 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL1100816 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL18139228 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL18139782 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL18141467 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL18141719 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL248072 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL18140912 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA | |
| SCHEMBL10878272 | 0.89 | THRA (0.56) | S1PR1S1PR3S1PR4S1PR2THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 229 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106604981-B | Lubricant compositions for improved thermo-oxidative stability and color stability | SK新技术株式会社 | 2020-02-07 | — | — | CN | claimed |
| WO-1999027014-A1 | HYDROCOLLOID WOUND DRESSING AND THE METHOD OF MAKING AND USING THE SAME | SHERWOOD SERVICES AG (CH) | 1999-06-03 | — | — | WO | claimed |
| CN-115698131-B | Curable thermoset compositions comprising poly (arylene ether) copolymers | 高新特殊工程塑料全球技术有限公司 | 2025-06-17 | — | — | CN | disclosed |
| CN-120153003-A | High-elasticity thermoplastic polyurethane and use thereof | 路博润先进材料公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-120076926-A | Thermoplastic battery cover reinforced with continuous fiber composite sheet to control burst pressure | SABIC环球技术有限责任公司 | 2025-05-30 | — | — | CN | disclosed |
| CN-120005361-A | Biodegradable resin composition and biodegradable molded article | 爱思开利比奥有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-119998360-A | Thermoplastic resin and molded body comprising thermoplastic resin | 三菱瓦斯化学株式会社 | 2025-05-13 | — | — | CN | disclosed |
| CN-119998400-A | Polycarbonate compositions, methods for preparing the same, and articles comprising the polycarbonate compositions | 高新特殊工程塑料全球技术有限公司 | 2025-05-13 | — | — | CN | disclosed |
| CN-119798886-A | PVC with fragrance and preparation method thereof | 苏州塑宝塑胶科技有限公司 | 2025-04-11 | — | — | CN | disclosed |
| CN-119768458-A | Thermoplastic composition, method of making the same, and articles made therefrom | 高新特殊工程塑料全球技术有限公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-119562991-A | Thermoplastic composition for laser direct structuring | MCE技术中心有限公司 | 2025-03-04 | — | — | CN | disclosed |
| EP-1576068-A1 | PACKAGING TAPE ADHESIVE COMPOSITION AND PACKAGING TAPE COMPRISING IT | KRATON Polymers Research B.V. (NL) | 2005-09-21 | — | — | EP | disclosed |
| US-6794341-B2 | A SLIPPING AGENT FOR SURFACE TREATMENT, COMPRISING AN EXTREME PRESSURE AGENT SELECTED FROM PHOSPHATE ESTERS AND PHOSPHITE ESTERS IN SOLVENT | CITIZEN WATCH CO., LTD. (JP) | 2004-09-21 | — | — | US | disclosed |
| US-20040147713-A1 | Polycarbonate resin for optical disk substrate and optical disk substrate | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2004-07-29 | — | — | US | disclosed |
| WO-2004056935-A1 | PACKAGING TAPE ADHESIVE COMPOSITION AND PACKAGING TAPE COMPRISING IT | KRATON POLYMERS RESEARCH B.V. (NL) | 2004-07-08 | — | — | WO | disclosed |
| EP-1386982-A1 | PEAK TORQUE LOWERING COMPOSITION, PART WITH SLIDING PART USING THE COMPOSITION, AND PRESS-FITTING METHOD USING THE COMPOSITION | Citizen Watch Co. Ltd. (JP) | 2004-02-04 | — | — | EP | disclosed |
| US-20030109387-A1 | Peak torque lowering composition, part with sliding part using the composition, and press-fitting method using the composition | CITIZEN WATCH CO., LTD. (JP) | 2003-06-12 | — | — | US | disclosed |
| EP-1313833-A1 | CLEANING AID | UNILEVER N.V. (NL) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018531-A1 | CLEANING AID | UNILEVER N.V. (NL) | 2002-03-07 | — | — | WO | disclosed |
| WO-1999027014-A1 | HYDROCOLLOID WOUND DRESSING AND THE METHOD OF MAKING AND USING THE SAME | SHERWOOD SERVICES AG (CH) | 1999-06-03 | — | — | WO | disclosed |