Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.44 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TK1 | P04183 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | TK2 | O00142 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL6461598 | 1.00 | DNMT1 (0.44) | DNMT1ADRB1LMNASMN1; SMN2TK1 | |
| SCHEMBL500621 | 0.96 | ADRB1 (0.47) | DNMT1ADRB1LMNASMN1; SMN2TK1 | |
| SCHEMBL1401331 | 0.91 | ADRB1 (0.44) | DNMT1ADRB1LMNASMN1; SMN2TK1 | |
| SCHEMBL2991978 | 0.86 | TYMS (0.47) | TYMSPOLB | |
| Tetrabuthylammonium SCHEMBL19462587 | 0.86 | ADRB1 (0.37) | DNMT1ADRB1LMNASMN1; SMN2TK1 | |
| SCHEMBL31685173 | 0.84 | ADRB1 (0.33) | DNMT1ADRB1POLB | |
| SCHEMBL154965 | 0.81 | POLB (0.45) | TYMSPOLB | |
| SCHEMBL1401335 | 0.81 | ADRB1 (0.34) | DNMT1ADRB1TYMSPOLB | |
| Phosphoric Acid SCHEMBL20305093 | 0.80 | LMNA (0.42) | DNMT1LMNASMN1; SMN2BLMPMP22 | |
| Phosphoric Acid SCHEMBL6465085 | 0.80 | LMNA (0.42) | DNMT1LMNASMN1; SMN2BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022454-A1 | METHODS, PRIMERS AND KITS FOR GENOTYPING NEOSPORA SPECIES AND STRAINS | UNIVERSITY OF TECHNOLOGY, SYDNEY (AU) | 2010-03-04 | — | — | WO | disclosed |