Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.37 |
| ▸ | HTR1E | P28566 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236982 | 0.90 | PTPN1 (0.39) | HTR1DHTR1EHTR1AADRA1DF10 | |
| SCHEMBL394705 | 0.80 | ASH1L (0.52) | IMPDH2ASH1L | |
| SCHEMBL389548 | 0.77 | PTPN1 (0.47) | HTR1DASH1L | |
| SCHEMBL51234 | 0.76 | NPC1 (0.53) | ASH1L | |
| SCHEMBL1173868 | 0.75 | NPC1 (0.54) | ASH1L | |
| Cyclohexanone SCHEMBL3244111 | 0.75 | PTPN1 (0.46) | — | |
| SCHEMBL1174476 | 0.74 | PTPN1 (0.48) | HTR1D | |
| SCHEMBL2901517 | 0.73 | GABRA1 (0.42) | HTR1DHTR1AIMPDH2ADRA1DF10 | |
| SCHEMBL1173806 | 0.73 | KMO (0.47) | ADRA1DF10 | |
| SCHEMBL1173489 | 0.72 | KMO (0.44) | ADRA1DF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029606-B1 | CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2010-05-26 | — | — | EP | disclosed |