Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389548 | 0.94 | PTPN1 (0.47) | PTPN1GAASPRACMSDKDM4E | |
| SCHEMBL1174476 | 0.90 | PTPN1 (0.48) | PTPN1SPRACMSDKDM4EALDH1A1 | |
| SCHEMBL3236982 | 0.85 | PTPN1 (0.39) | PTPN1CCNE1CDK2CCNT1CCNK | |
| SCHEMBL394705 | 0.80 | ASH1L (0.52) | PARP1 | |
| SCHEMBL14572834 | 0.78 | PTPN1 (0.53) | PTPN1SPRKDM4EALDH1A1HPGD | |
| SCHEMBL3236973 | 0.75 | HTR1D (0.37) | — | |
| SCHEMBL17805786 | 0.73 | IMPDH2 (0.49) | KDM4EALDH1A1HSD17B10CCNE1CDK2 | |
| SCHEMBL12127320 | 0.73 | IMPDH2 (0.49) | KDM4EALDH1A1HSD17B10TDO2 | |
| Ethylene SCHEMBL7484422 | 0.71 | TDO2 (0.53) | TDO2 | |
| SCHEMBL12127335 | 0.71 | SLC6A4 (0.52) | CCNE1CDK2PARP1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029606-B1 | CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2010-05-26 | — | — | EP | disclosed |