Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3120660 | 0.89 | GAA (0.49) | GAATSHRMAPTTDP1HRH3 | |
| SCHEMBL3249745 | 0.88 | GAA (0.49) | GAATSHRMAPTTDP1L3MBTL1 | |
| SCHEMBL3126815 | 0.86 | GAA (0.51) | GAATSHRMAPTTDP1L3MBTL1 | |
| SCHEMBL3119103 | 0.81 | GAA (0.42) | GAATSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL3241489 | 0.77 | TSHR (0.46) | GAATSHRMAPTTDP1HPGD | |
| SCHEMBL3248197 | 0.77 | TSHR (0.46) | GAATSHRMAPTTDP1HPGD | |
| SCHEMBL3252753 | 0.76 | TSHR (0.44) | GAATSHRMAPTTDP1HPGD | |
| SCHEMBL13521588 | 0.76 | TSHR (0.52) | GAATSHRMAPTL3MBTL1CYP2D6 | |
| SCHEMBL3236789 | 0.76 | GAA (0.55) | GAATSHRMAPTHPGDSMN1; SMN2 | |
| SCHEMBL13521713 | 0.75 | TSHR (0.44) | GAATSHRMAPTTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |