Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119103 | 0.93 | GAA (0.42) | GAATSHRALDH1A1ESR2POLB | |
| SCHEMBL3120660 | 0.92 | GAA (0.49) | GAATSHRTAAR1MAPTALDH1A1 | |
| SCHEMBL3126815 | 0.88 | GAA (0.51) | GAATSHRMAPTALDH1A1TDP1 | |
| SCHEMBL3237347 | 0.88 | GAA (0.48) | GAATSHRMAPTALDH1A1TDP1 | |
| SCHEMBL3241489 | 0.87 | TSHR (0.46) | GAATSHRTAAR1MAPTALDH1A1 | |
| SCHEMBL3240895 | 0.87 | TAAR1 (0.43) | GAATSHRTAAR1MAPTALDH1A1 | |
| SCHEMBL3252753 | 0.86 | TSHR (0.44) | GAATSHRTAAR1MAPTALDH1A1 | |
| SCHEMBL13521636 | 0.86 | TSHR (0.50) | GAATSHRTAAR1MAPTALDH1A1 | |
| SCHEMBL3249334 | 0.85 | MAPK1 (0.42) | GAATSHRTAAR1MAPTALDH1A1 | |
| SCHEMBL13521713 | 0.85 | TSHR (0.44) | GAATSHRTAAR1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |