Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 6/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94133 | 0.98 | POLB (0.59) | POLBSMN1; SMN2MAOAMAOBLOXL2 | |
| SCHEMBL29934196 | 0.98 | POLB (0.59) | POLBSMN1; SMN2MAOAMAOBLOXL2 | |
| Butane SCHEMBL20446706 | 0.92 | MAOB (0.62) | POLBSMN1; SMN2MAOAMAOBLOXL2 | |
| Carbamic Acid SCHEMBL8995121 | 0.90 | MMP2 (0.56) | POLBSMN1; SMN2MAOAMAOBLOXL2 | |
| Acetic Acid SCHEMBL472753 | 0.89 | MAOB (0.56) | POLBSMN1; SMN2MAOAMAOBMMP2 | |
| Coumarin SCHEMBL17312324 | 0.89 | CA12 (0.61) | POLBSMN1; SMN2MAOAMAOBLOXL2 | |
| SCHEMBL30311162 | 0.84 | MMP2 (0.60) | POLBSMN1; SMN2MAOAMAOBLOXL2 | |
| SCHEMBL5678818 | 0.84 | MAOA (0.52) | POLBSMN1; SMN2MAOAMAOBLOXL2 | |
| SCHEMBL13612673 | 0.83 | MAOA (0.61) | POLBSMN1; SMN2MAOAMAOBMMP2 | |
| SCHEMBL27625488 | 0.83 | MMP2 (0.67) | POLBSMN1; SMN2MAOAMAOBMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2236619-A2 | BCL2L12 polypeptide activators and inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2010-10-06 | — | — | EP | disclosed |
| US-7595158-B2 | Bcl2L12 polypeptide activators and inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| EP-1618217-A4 | BCL2L12 POLYPEPTIDE ACTIVATORS AND INHIBITORS | DANA FARBER CANCER INST INC (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20060252053-A1 | Bcl2L12 polypeptide activators and inhibitors | DANA-FARBER CANCER INSTITUTE, INC. | 2006-11-09 | — | — | US | disclosed |
| EP-1618217-A2 | BCL2L12 POLYPEPTIDE ACTIVATORS AND INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004096991-A2 | BCL2L12 POLYPEPTIDE ACTIVATORS AND INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2004-11-11 | — | — | WO | disclosed |