Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235310 | 0.89 | SMN1; SMN2 (0.42) | SMN1; SMN2TP53KMT2ACD274NPC1 | |
| SCHEMBL3231465 | 0.89 | ALDH1A1 (0.44) | SMN1; SMN2TP53CD274RAB9AMAPT | |
| SCHEMBL3233338 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2TP53MEN1KMT2ACD274 | |
| SCHEMBL3230749 | 0.86 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53MEN1KMT2ACD274 | |
| SCHEMBL3233720 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APOLBPTGER1 | |
| SCHEMBL3231470 | 0.80 | TP53 (0.48) | SMN1; SMN2TP53MEN1KMT2AMAPT | |
| SCHEMBL3995327 | 0.77 | GUCY1B2 (0.47) | SMN1; SMN2CD274NPC1RAB9AS1PR5 | |
| SCHEMBL3238099 | 0.77 | HPGD (0.41) | SMN1; SMN2TP53MEN1KMT2ACD274 | |
| SCHEMBL3230733 | 0.76 | LTA4H (0.40) | SMN1; SMN2TP53MEN1KMT2ACD274 | |
| SCHEMBL3231553 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2TP53MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |