Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249427 | 0.85 | GNE (0.68) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL3244751 | 0.84 | GNE (0.66) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL28467301 | 0.83 | GNE (0.51) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL30911660 | 0.81 | RAB9A (0.50) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1554586 | 0.81 | RAB9A (0.50) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL30911663 | 0.81 | RAB9A (0.50) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL947448 | 0.81 | HTR2C (0.54) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL31395167 | 0.81 | HRH4 (0.53) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL30149935 | 0.81 | RAB9A (0.52) | HTR2CNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4122541 | 0.81 | RAB9A (0.52) | HTR2CNPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2186516-B1 | Novel benzazepine derivative | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | disclosed |
| EP-2133340-B1 | Novel benzazepine derivatives | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | disclosed |
| EP-2186516-A1 | Novel benzazepine derivative | Glaxo Group Limited (GB) | 2010-05-19 | — | — | EP | disclosed |
| EP-2133340-A1 | Novel benzazepine derivatives | Glaxo Group Limited (GB) | 2009-12-16 | — | — | EP | disclosed |
| EP-1572215-B1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LTD (GB) | 2009-09-02 | — | — | EP | disclosed |