Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.62 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13457054 | 0.87 | ROCK2 (0.64) | MAOBBTKROCK2PDGFRBKIT | |
| SCHEMBL3268110 | 0.77 | ROCK2 (0.66) | MAOBROCK2RPS6KB1 | |
| SCHEMBL15662764 | 0.77 | BTK (0.77) | BTKROCK2AKT2PDGFRBKIT | |
| SCHEMBL3264656 | 0.75 | ROCK2 (0.68) | MAOBROCK2RPS6KB1 | |
| SCHEMBL13457308 | 0.72 | ROCK2 (0.69) | ROCK2JAK3 | |
| SCHEMBL16793763 | 0.71 | BTK (0.67) | BTKPDGFRBKITFLT3MAP3K19 | |
| SCHEMBL15661937 | 0.71 | JAK2 (0.67) | BTKFLT3RPS6KB1JAK3 | |
| SCHEMBL13362826 | 0.71 | MMP13 (0.51) | MAOBBTKROCK2PDGFRBKIT | |
| SCHEMBL15660156 | 0.70 | BTK (0.57) | BTKROCK2AKT2PDGFRBKIT | |
| SCHEMBL1230560 | 0.70 | TTBK1 (0.49) | BTKAKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |