Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.68 |
| ▸ | MAOB | P27338 | 3/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.58 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PRKACB | P22694 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13457054 | 0.88 | ROCK2 (0.64) | ROCK2MAOBRPS6KB1ROCK1 | |
| SCHEMBL3268110 | 0.88 | ROCK2 (0.66) | ROCK2MAOBRPS6KB1 | |
| SCHEMBL13457535 | 0.81 | ROCK2 (1.00) | ROCK2MAOBROCK1CDC42BPAPRKACA | |
| SCHEMBL20445828 | 0.77 | RPS6KB1 (1.00) | RPS6KB1 | |
| SCHEMBL3253956 | 0.77 | RPS6KB1 (0.57) | ROCK2RPS6KB1ROCK1 | |
| SCHEMBL3261601 | 0.77 | MAOB (0.78) | ROCK2MAOBROCK1 | |
| SCHEMBL3264837 | 0.76 | ROCK2 (0.56) | ROCK2RPS6KB1ROCK1CDC42BPAMAPK10 | |
| SCHEMBL3239363 | 0.75 | MAOB (0.62) | ROCK2MAOBRPS6KB1 | |
| SCHEMBL18176583 | 0.72 | RPS6KB1 (0.61) | ROCK2RPS6KB1ROCK1CDC42BPA | |
| SCHEMBL13362826 | 0.71 | MMP13 (0.51) | ROCK2MAOBRPS6KB1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |