Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCH | P24723 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239488 | 0.81 | BRAF (0.47) | BRAFEGFRPRKD3PRKCGPRKCB | |
| SCHEMBL16248315 | 0.70 | BRAF (0.54) | BRAFEGFRMEN1KMT2A | |
| SCHEMBL6893754 | 0.68 | FYN (0.48) | BRAFEGFRPRKD3PRKCGPRKCB | |
| SCHEMBL3244847 | 0.66 | PLK1 (0.56) | BRAFEGFRLCKABCB1ABCC1 | |
| SCHEMBL6976607 | 0.65 | ZAP70 (0.69) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL4035868 | 0.63 | IGF1R (0.73) | BRAFEGFRMEN1KMT2A | |
| SCHEMBL2765544 | 0.63 | ALDH1A1 (0.41) | EGFRMEN1KMT2ATUBB4ATUBB | |
| SCHEMBL2763893 | 0.63 | CYP2A6 (0.44) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL1122019 | 0.62 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL6975402 | 0.62 | ZAP70 (0.82) | EGFRPRKD3PRKCGPRKCBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |