Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.73 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.65 |
| ▸ | ULK1 | O75385 | 1/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.56 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12574176 | 0.83 | IGF1R (0.54) | IGF1RPTK2ULK1TGFBR1SMN1; SMN2 | |
| SCHEMBL19654202 | 0.81 | PTK2 (0.78) | IGF1RPTK2ULK1EGFRAXL | |
| SCHEMBL29575113 | 0.80 | PTK2 (1.00) | IGF1RPTK2ULK1EGFR | |
| SCHEMBL17547491 | 0.80 | PTK2 (1.00) | IGF1RPTK2ULK1EGFR | |
| SCHEMBL2284106 | 0.80 | IGF1R (0.63) | IGF1RPTK2SMN1; SMN2GAKRIPK2 | |
| SCHEMBL3948364 | 0.78 | GAK (0.60) | IGF1RTGFBR1BRAFGAKRIPK2 | |
| SCHEMBL17547449 | 0.78 | ULK1 (1.00) | IGF1RPTK2ULK1EGFR | |
| SCHEMBL29575547 | 0.78 | ULK1 (1.00) | IGF1RPTK2ULK1EGFR | |
| SCHEMBL3911186 | 0.77 | ABCG2 (0.56) | IGF1RSMN1; SMN2MEN1KMT2A | |
| SCHEMBL16248315 | 0.76 | BRAF (0.54) | IGF1RPTK2TGFBR1BRAFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENRIFIQUE (CNRS) | 2011-06-30 | — | — | US | disclosed |
| WO-2009147217-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009022171-A1 | PYRIDINYIIOXY PYRIDINES AS ALK5 INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | TUBB4A, TUBA4A, TUBGCP4 | IGF1R 1493/4885PTK2 857/4885ULK1 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.