Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.56 |
| ▸ | CTSC | P53634 | 3/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.48 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.48 |
| ▸ | TXK | P42681 | 1/20 | 0.48 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893754 | 0.80 | FYN (0.48) | HPGDEGFRLCKBRAFABCB1 | |
| SCHEMBL3243306 | 0.75 | CTSC (0.70) | CTSCKDM4EALDH1A1GAAHPGD | |
| SCHEMBL21017078 | 0.75 | ALDH1A1 (0.48) | CTSCALDH1A1GAA | |
| SCHEMBL4338170 | 0.74 | PIK3CG (0.69) | PLK1PLK3PTK2 | |
| SCHEMBL3243096 | 0.74 | CTSC (0.61) | CTSCKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3246053 | 0.74 | CTSC (0.62) | CTSCKDM4EALDH1A1GAAHPGD | |
| SCHEMBL11161140 | 0.73 | KIF11 (0.47) | CTSCKDM4EALDH1A1GAA | |
| SCHEMBL16248315 | 0.72 | BRAF (0.54) | PTK2KDM4EGAAEGFRBRAF | |
| SCHEMBL3246389 | 0.72 | CTSC (0.58) | CTSCKDM4EALDH1A1GAAHPGD | |
| Gw837331X SCHEMBL3996619 | 0.72 | PLK1 (1.00) | PLK1PLK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |