Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347867 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HPGDSKDM4EMAPTPLA2G10 | |
| SCHEMBL25413652 | 0.83 | KDM4E (0.62) | ALDH1A1KDM4EMAPTPLA2G10MEN1 | |
| SCHEMBL9911663 | 0.79 | ALDH1A1 (0.56) | ALDH1A1PLA2G10PTPN1 | |
| SCHEMBL3412110 | 0.77 | ALDH1A1 (0.71) | ALDH1A1HPGDSKDM4EMAPTPLA2G10 | |
| SCHEMBL31341221 | 0.77 | ALDH1A1 (0.61) | ALDH1A1HPGDSKDM4EPLA2G10ACHE | |
| SCHEMBL6786585 | 0.76 | ALDH1A1 (0.63) | ALDH1A1HPGDSKDM4EPLA2G10ACHE | |
| Hydrochloric Acid SCHEMBL6821165 | 0.75 | ALDH1A1 (0.69) | ALDH1A1HPGDSKDM4EMAPTPLA2G10 | |
| SCHEMBL4355343 | 0.75 | TLR7 (0.64) | ALDH1A1HPGDSKDM4EMAPTPLA2G10 | |
| SCHEMBL26319829 | 0.75 | PRKD3 (0.51) | ALDH1A1HPGDSKDM4ENPC1RAB9A | |
| SCHEMBL12943990 | 0.75 | PRKAG1 (0.40) | ALDH1A1HPGDSKDM4EMAPTPLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-04-22 | — | — | US | disclosed |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-04-22 | — | — | US | disclosed |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-04-22 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| WO-2009131952-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING THIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | ALDH1A1 2115/4885HPGDS 349/4885KDM4E 4565/4885 |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | CFTR, PKD1, PKD2 | ALDH1A1 1738/4885HPGDS 754/4885KDM4E 4555/4885 |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | CFTR, PKD1, PKD2 | ALDH1A1 2115/4885HPGDS 349/4885KDM4E 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.