Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 5/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263743 | 1.00 | LCK (0.40) | LCKJAK3KMT2AMEN1BTK | |
| SCHEMBL3240119 | 0.85 | LCK (0.48) | LCKJAK3KMT2AMEN1BTK | |
| SCHEMBL3232842 | 0.80 | ROS1 (0.43) | LCKJAK3KMT2AMEN1BTK | |
| SCHEMBL3242367 | 0.76 | LCK (0.48) | LCKJAK3KMT2AMEN1BTK | |
| SCHEMBL13303594 | 0.75 | BTK (0.46) | LCKJAK3KMT2ABTKEGFR | |
| SCHEMBL9984843 | 0.73 | BTK (0.47) | LCKJAK3KMT2AMEN1BTK | |
| SCHEMBL9985224 | 0.73 | BTK (0.49) | LCKJAK3KMT2ABTKEGFR | |
| SCHEMBL3263178 | 0.73 | BTK (0.45) | LCKJAK3KMT2ABTKEGFR | |
| SCHEMBL2491482 | 0.72 | BTK (0.58) | LCKJAK3KMT2ABTKEGFR | |
| SCHEMBL3263477 | 0.72 | LCK (0.45) | LCKJAK3KMT2ABTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |