Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223302 | 0.80 | NOTUM (0.38) | TSHRNOTUMCHRM1 | |
| SCHEMBL23451696 | 0.78 | NOTUM (0.51) | ALDH1A1ALOX12SMN1; SMN2NOTUMLMNA | |
| SCHEMBL7227830 | 0.67 | NOTUM (0.44) | TSHRALDH1A1ALOX12SMN1; SMN2NOTUM | |
| SCHEMBL4559227 | 0.63 | F9 (0.36) | HSD17B10TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL7762159 | 0.63 | NOTUM (0.42) | TSHRALDH1A1ALOX15SMN1; SMN2NOTUM | |
| SCHEMBL2215697 | 0.62 | NOTUM (0.49) | ALDH1A1TTRSMN1; SMN2NOTUMPOLB | |
| SCHEMBL8872103 | 0.62 | HSD17B10 (1.00) | HSD17B10TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL184648 | 0.62 | HSD17B10 (1.00) | HSD17B10TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL12263160 | 0.61 | NOTUM (0.55) | TTRSMN1; SMN2NOTUMPOLBMAPT | |
| SCHEMBL2808115 | 0.60 | HSD17B10 (0.93) | HSD17B10TSHRALDH1A1CYP3A4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | HSD17B10 1275/4885TSHR 2802/4885ALDH1A1 2115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.