Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240488 | 1.00 | PIM1 (0.37) | PIM1PIM2CCNT1NOS1NOS2 | |
| SCHEMBL2022964 | 0.86 | PIM1 (0.35) | PIM1PIM2CCNT1NOS1NOS2 | |
| SCHEMBL3236457 | 0.82 | MAPK1 (0.37) | PIM1CCNT1CDK2MAPK3CDC7 | |
| SCHEMBL3236327 | 0.81 | CHRM3 (0.47) | PIM1NOS1NOS2CDK2CCNA2 | |
| SCHEMBL2022965 | 0.78 | PIM1 (0.35) | PIM1PIM2CCNT1NOS1NOS2 | |
| SCHEMBL2019860 | 0.73 | PDE4D (0.39) | CCNT1CDK2MAPK3CDK9 | |
| SCHEMBL3231825 | 0.70 | PGK1 (0.42) | — | |
| SCHEMBL2021429 | 0.69 | NUDT1 (0.46) | PIM1PIM2CDK2CCNA2 | |
| SCHEMBL25136216 | 0.67 | CD38 (0.49) | CDK2CCNA2PTGER1CD38GSK3A | |
| SCHEMBL30182757 | 0.67 | CD38 (0.49) | CDK2CCNA2PTGER1CD38GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010027097-A1 | TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-11 | — | — | WO | disclosed |