Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 8/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.36 |
| ▸ | RPS6KA1 | Q15418 | 5/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 6/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019860 | 0.82 | PDE4D (0.39) | MAPK1MAPK3RPS6KA1CCNT1CDK2 | |
| SCHEMBL3240488 | 0.82 | PIM1 (0.37) | MAPK3CCNT1CDK2PIM1CDC7 | |
| SCHEMBL3240478 | 0.82 | PIM1 (0.37) | MAPK3CCNT1CDK2PIM1CDC7 | |
| SCHEMBL3233648 | 0.80 | CHRM3 (0.47) | CDK2CCNE1PIK3CA | |
| SCHEMBL2019862 | 0.76 | MAPK1 (0.36) | MAPK1MAPK3RPS6KA1CCNT1HDAC3 | |
| SCHEMBL3199851 | 0.73 | OPRK1 (0.51) | MAPK1CCNT1PIM1MEN1KMT2A | |
| SCHEMBL3231825 | 0.72 | PGK1 (0.42) | — | |
| SCHEMBL3713155 | 0.69 | TDP1 (0.41) | MAPK1MAPK3RPS6KA1CCNT1HDAC3 | |
| SCHEMBL2019542 | 0.67 | CCNT1 (0.41) | MAPK1MAPK3RPS6KA1CCNT1CDK2 | |
| SCHEMBL15229185 | 0.66 | MEN1 (0.71) | MAPK1MAPK3CCNT1CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010027097-A1 | TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-11 | — | — | WO | disclosed |