Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238928 | 0.88 | PARP10 (0.62) | OPRM1OPRD1OPRK1MAPK1PARP10 | |
| SCHEMBL3239373 | 0.88 | PARP10 (0.62) | OPRM1OPRD1OPRK1MAPK1PARP10 | |
| SCHEMBL13271096 | 0.87 | PLK1 (0.51) | OPRM1OPRD1MAPK1EPHX2 | |
| SCHEMBL1790025 | 0.80 | RARB (0.54) | MAPK1PARP10ALDH1A1THRBTSHR | |
| SCHEMBL3238389 | 0.79 | PARP10 (0.56) | OPRM1OPRD1OPRK1PARP10ALDH1A1 | |
| SCHEMBL1532866 | 0.78 | OPRM1 (0.70) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3694759 | 0.78 | OPRM1 (0.61) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3238903 | 0.78 | MAOB (0.52) | OPRM1OPRD1OPRK1PARP10ALDH1A1 | |
| SCHEMBL18232515 | 0.78 | TDP1 (0.46) | MAPK1EPHX2 | |
| SCHEMBL9637572 | 0.77 | MAPK1 (0.73) | MAPK1PARP10ALDH1A1THRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727788-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-07-28 | — | — | EP | claimed |
| US-7381750-B2 | Amino-phenoxymethyl-benzamide opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-06-03 | — | — | US | claimed |
| US-20070287751-A1 | Opioid Receptor Antagonists | ELI LILLY AND COMPANY | 2007-12-13 | — | — | US | claimed |
| EP-1727788-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-12-06 | — | — | EP | claimed |
| WO-2005090286-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | claimed |
| EP-1727788-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-07-28 | — | — | EP | disclosed |
| US-7381750-B2 | Amino-phenoxymethyl-benzamide opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381750-B2 | Amino-phenoxymethyl-benzamide opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381750-B2 | Amino-phenoxymethyl-benzamide opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-20070287751-A1 | Opioid Receptor Antagonists | ELI LILLY AND COMPANY | 2007-12-13 | — | — | US | disclosed |
| US-20070287751-A1 | Opioid Receptor Antagonists | ELI LILLY AND COMPANY | 2007-12-13 | — | — | US | disclosed |
| US-20070287751-A1 | Opioid Receptor Antagonists | ELI LILLY AND COMPANY | 2007-12-13 | — | — | US | disclosed |
| EP-1727788-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005090286-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287751-A1 | Opioid Receptor Antagonists | OPRK1, OPRM1, OPRD1 | OPRM1 2/4885OPRD1 3/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.