Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 4/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238815 | 0.88 | PDE4A (0.44) | P2RX7TP53MAPTTOP1 | |
| SCHEMBL3228576 | 0.88 | SERPINE1 (0.52) | SERPINE1TOP1LMNAALDH1A1 | |
| SCHEMBL3237157 | 0.88 | MAPT (0.48) | TP53MAPTTOP1THRB | |
| SCHEMBL3243021 | 0.86 | SERPINE1 (0.49) | SERPINE1TP53MAPTLMNAFEN1 | |
| SCHEMBL3242072 | 0.83 | ICMT (0.50) | P2RX7TP53MAPTLMNAALDH1A1 | |
| SCHEMBL3236676 | 0.83 | CHRM1 (0.55) | SERPINE1TP53LMNA | |
| SCHEMBL6202850 | 0.81 | HPGD (0.47) | MAPTLMNAALDH1A1 | |
| SCHEMBL3236698 | 0.80 | CHRM1 (0.54) | SERPINE1 | |
| SCHEMBL6214042 | 0.78 | PIM1 (0.42) | MAPTTOP1LMNAALDH1A1 | |
| SCHEMBL3241350 | 0.78 | CHRM1 (0.56) | SERPINE1P2RX7FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |