Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238815 | 0.90 | PDE4A (0.44) | ICMTMAPTTP53P2RX7KDM4E | |
| SCHEMBL3236944 | 0.87 | ICMT (0.52) | ICMTLMNAATM | |
| SCHEMBL3238079 | 0.87 | ICMT (0.45) | ICMTMAPTLMNATP53RXFP1 | |
| SCHEMBL3237157 | 0.84 | MAPT (0.48) | MAPTTP53RXFP1GAASMN1; SMN2 | |
| SCHEMBL3241407 | 0.83 | SERPINE1 (0.46) | MAPTLMNATP53P2RX7ALDH1A1 | |
| SCHEMBL3234280 | 0.82 | CHRM1 (0.49) | ICMTMAPTLMNATP53RXFP1 | |
| SCHEMBL6202850 | 0.79 | HPGD (0.47) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL3242155 | 0.79 | CHRM1 (0.45) | ICMTMAPTLMNATP53RXFP1 | |
| SCHEMBL3237953 | 0.77 | TOP1 (0.53) | LMNA | |
| SCHEMBL6214042 | 0.76 | PIM1 (0.42) | MAPTLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |