Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238815 | 0.89 | PDE4A (0.44) | MAPTPRNPTP53TOP1 | |
| SCHEMBL3241407 | 0.88 | SERPINE1 (0.46) | MAPTTP53THRBTOP1 | |
| SCHEMBL3234629 | 0.85 | TP53 (0.50) | MAPTPRNPTP53RXFP1THRB | |
| SCHEMBL3237152 | 0.85 | TOP1 (0.57) | MAPTPRNPTP53RXFP1TOP1 | |
| SCHEMBL3242072 | 0.84 | ICMT (0.50) | MAPTTP53RXFP1SMN1; SMN2GAA | |
| SCHEMBL6202850 | 0.84 | HPGD (0.47) | MAPTPOLBGAAMEN1KMT2A | |
| SCHEMBL8130462 | 0.83 | LMNA (0.47) | MEN1KMT2A | |
| SCHEMBL6214042 | 0.83 | PIM1 (0.42) | MAPTPOLBTOP1MEN1KMT2A | |
| SCHEMBL30064588 | 0.81 | PPARD (0.46) | MAPTPRNPTP53RXFP1POLB | |
| SCHEMBL3239683 | 0.79 | P2RX3 (0.43) | MAPTPRNPTP53RXFP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |