Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249318 | 0.90 | RET (0.48) | KDM4EALDH1A1HPGDRETSMN1; SMN2 | |
| SCHEMBL3252215 | 0.85 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL3247067 | 0.81 | CSNK2A2 (0.43) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4163219 | 0.81 | GPR17 (0.38) | KDM4EALDH1A1HPGDRETSMN1; SMN2 | |
| SCHEMBL3244469 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL3248781 | 0.78 | KDM4E (0.40) | KDM4EALDH1A1HPGDRETSMN1; SMN2 | |
| SCHEMBL3247132 | 0.76 | PKM (0.39) | KDM4EALDH1A1HPGDRETPOLB | |
| SCHEMBL3243089 | 0.76 | CYP1A2 (0.45) | KDM4EALDH1A1POLBGAACYP1A2 | |
| SCHEMBL3254551 | 0.75 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDRETPOLB | |
| SCHEMBL3249118 | 0.74 | KDM4E (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |