Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857449 | 0.76 | TDP1 (0.45) | KDM4ETDP1NR4A2L3MBTL1PKM | |
| SCHEMBL812065 | 0.74 | KDM4E (0.59) | KDM4ETDP1MAP2K1TSHRL3MBTL1 | |
| Tert-Butyl Formate SCHEMBL28781508 | 0.73 | MAP2K1 (0.41) | KDM4ETDP1MAP2K1NR4A2TSHR | |
| SCHEMBL7649536 | 0.73 | TDP1 (0.59) | KDM4ETDP1MAP2K1TSHRL3MBTL1 | |
| SCHEMBL12166081 | 0.73 | KDM4E (0.52) | KDM4ETDP1MAP2K1NR4A2L3MBTL1 | |
| SCHEMBL31668450 | 0.70 | ALDH1A1 (0.54) | KDM4ETDP1TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL27504693 | 0.70 | ALDH1A1 (0.54) | KDM4ETDP1TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL28120694 | 0.69 | TDP1 (0.50) | KDM4ETDP1MAP2K1TSHRL3MBTL1 | |
| SCHEMBL29664560 | 0.69 | TDP1 (0.54) | KDM4ETDP1MAP2K1TSHRL3MBTL1 | |
| SCHEMBL645854 | 0.69 | TDP1 (0.54) | KDM4ETDP1MAP2K1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |