Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.39 |
| ▸ | DPP4 | P27487 | 7/20 | 0.39 |
| ▸ | FAP | Q12884 | 7/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL771483 | 0.85 | NPC1 (0.53) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL771464 | 0.85 | DRD2 (0.51) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL770711 | 0.84 | NPC1 (0.47) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL770709 | 0.82 | NPC1 (0.44) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19416135 | 0.81 | DRD2 (0.49) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL793909 | 0.81 | DRD2 (0.49) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL770615 | 0.81 | DRD2 (0.49) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11811900 | 0.81 | DRD2 (0.52) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL770256 | 0.81 | DRD2 (0.52) | DRD2DRD4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL794344 | 0.81 | DRD2 (0.49) | DRD2DRD4NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586577-B2 | Diazepane acetamide derivatives as selective 11B-HSD1 inhibitors | MERCK PATENT GMBH (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20120283247-A1 | DIAZEPANE ACETAMIDE DERIVATIVES AS SELECTIVE 11B-HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-11-08 | — | — | US | disclosed |
| US-8242107-B2 | Diazepane-acetamide derivatives as selective 11β-HSD1 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-08-14 | — | — | US | disclosed |
| EP-2078001-B8 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-12-15 | — | — | EP | disclosed |
| EP-2078001-B1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-05-12 | — | — | EP | disclosed |
| US-20100069365-A1 | Diazepane-acetamide derivatives as selective 11B-HSD1 inhibitors | MERCK PATENT GMBH (DE) | 2010-03-18 | — | — | US | disclosed |
| EP-2078001-A1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | Merk Patent Gmbh (DE) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008052638-A1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS | MERK PATENT GMBH (DE) | 2008-05-08 | — | — | WO | disclosed |
| EP-1918285-A1 | Diazepane-acetamide derivatives as selective 11beta-HSD1 inhibitors | Merck Sante (FR) | 2008-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069365-A1 | Diazepane-acetamide derivatives as selective 11B-HSD1 inhibitors | HSD11B1, HSD11B2, HSD17B1 | DRD2 1580/4885DRD4 1882/4885NPC1 689/4885 |
| US-20120283247-A1 | DIAZEPANE ACETAMIDE DERIVATIVES AS SELECTIVE 11B-HSD1 INHIBITORS | HSD11B1, HSD11B2, HSD17B1 | DRD2 1415/4885DRD4 1734/4885NPC1 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.