Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242562 | 0.83 | HSD17B10 (0.49) | HSD17B10NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7782009 | 0.79 | MAPT (0.53) | HSD17B10RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL2470133 | 0.76 | LMNA (0.55) | HSD17B10SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL19760841 | 0.75 | KDM4E (0.54) | HSD17B10NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL9396501 | 0.74 | CA12 (0.51) | HSD17B10MAOASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7786715 | 0.71 | MAPT (0.53) | HSD17B10RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL13152964 | 0.71 | MAOA (0.45) | HSD17B10NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL19195619 | 0.70 | KDM4E (0.49) | HSD17B10NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL18927126 | 0.70 | KDM4E (0.49) | HSD17B10NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL20349961 | 0.70 | MAOA (0.54) | HSD17B10NPC1RAB9AMAOASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1642895-B1 | Novel substituted naphthopyrans | TRANSITIONS OPTICAL INC (US) | 2010-03-31 | — | — | EP | disclosed |
| EP-1642895-A2 | Novel substituted naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2006-04-05 | — | — | EP | disclosed |
| EP-0954522-B1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-0954522-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | PPG Industries Ohio, Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
| EP-0954522-A4 | NOVEL SUBSTITUTED NAPHTHOPYRANS | PPG IND OHIO INC (US) | 1999-06-21 | — | — | EP | disclosed |
| US-5651923-A | PHOTOCHROMIC ARTICLE | TRANSITIONS OPTICAL, INC. (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1997021698-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1997-06-19 | — | — | WO | disclosed |