Sugi Predict

Sugi Predict / Compounds / SCHEMBL2470133

SCHEMBL2470133

SCHEMBL2470133

COC(=O)c1cc(O)c2ccccc2c1C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.55
▸ TSHR P16473 1/20 0.55
▸ KDM4E B2RXH2 5/20 0.50
▸ MAPT P10636 3/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ NSD2 O96028 1/20 0.50
▸ POLB P06746 1/20 0.50
▸ MCL1 Q07820 1/20 0.50
▸ CA1 P00915 3/20 0.47
▸ CA2 P00918 3/20 0.47
▸ CA9 Q16790 3/20 0.47
▸ CA5A P35218 1/20 0.47
▸ CA12 O43570 2/20 0.47
▸ CA7 P43166 2/20 0.47
▸ CA14 Q9ULX7 2/20 0.47
▸ THRB P10828 1/20 0.47
▸ PDK2 Q15119 1/20 0.47
▸ PDK4 Q16654 1/20 0.47
▸ ALDH1A1 P00352 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1791233 0.84 KDM4E (0.66) LMNATSHRKDM4EMAPTMEN1
SCHEMBL28283410 0.81 LMNA (0.53) LMNATSHRKDM4EMAPTMEN1
SCHEMBL20123231 0.81 KDM4E (0.52) LMNATSHRKDM4EMAPTPOLB
SCHEMBL244414 0.81 KDM4E (0.45) LMNATSHRKDM4EMEN1KMT2A
SCHEMBL6172886 0.81 NR4A2 (0.51) KDM4EMAPTMEN1KMT2APOLB
SCHEMBL2469996 0.81 NR4A2 (0.51) LMNATSHRMAPTCA1CA2
SCHEMBL7782009 0.81 MAPT (0.53) LMNATSHRKDM4EMAPTMEN1
SCHEMBL7786715 0.81 MAPT (0.53) LMNATSHRKDM4EMAPTMEN1
SCHEMBL7596065 0.80 THRB (0.67) LMNATSHRKDM4EMAPTMEN1
SCHEMBL7786707 0.79 LMNA (0.44) LMNATSHRKDM4EMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105199708-B Photochromic compounds 光学转变公司 2020-10-27 — — CN disclosed
EP-2370420-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-11-13 — — EP disclosed
EP-2370420-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-05-22 — — EP disclosed
US-20180291009-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291007-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291008-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-10005763-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-26 — — US disclosed
US-10000472-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-19 — — US disclosed
US-20160333262-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2016-11-17 — — US disclosed
US-20160332995-A1 Photochromic Comounds TRANSITIONS OPTICAL, INC. 2016-11-17 — — US disclosed
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-08-09 — — US disclosed
US-8211338-B2 Photochromic compounds TRANSITIONS OPTICAL, INC (US) 2012-07-03 — — US disclosed
EP-2370420-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-10-05 — — EP disclosed
WO-2010065393-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2010-06-10 — — WO disclosed
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2009-12-17 — — US disclosed
EP-1000025-B1 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2007-02-21 — — EP disclosed
EP-1000025-A4 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2002-10-09 — — EP disclosed
EP-1000025-A1 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2000-05-17 — — EP disclosed
WO-1998055457-A1 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 1998-12-10 — — WO disclosed
US-5658500-A REVERSIBLE PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 1997-08-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180291007-A1 Photochromic Compounds CCR4, CCR8, CBR3 LMNA 2300/4885TSHR 196/4885KDM4E 1714/4885
US-20160332995-A1 Photochromic Comounds CCR4, CCR3, CCR8 LMNA 1810/4885TSHR 239/4885KDM4E 2470/4885
US-10005763-B2 Photochromic compounds CCR4, CCR8, CBR3 LMNA 2309/4885TSHR 196/4885KDM4E 1710/4885
US-20180291008-A1 Photochromic Compounds CCR4, CBR3, CCR8 LMNA 2174/4885TSHR 180/4885KDM4E 1738/4885
US-20160333262-A1 Photochromic Compounds CCR4, CCR8, CBR3 LMNA 2309/4885TSHR 196/4885KDM4E 1710/4885
US-20180291009-A1 Photochromic Compounds CCR4, CCR8, CBR3 LMNA 2298/4885TSHR 188/4885KDM4E 1721/4885
US-10000472-B2 Photochromic compounds CCR4, CCR8, CBR3 LMNA 2309/4885TSHR 196/4885KDM4E 1710/4885
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 LMNA 2311/4885TSHR 205/4885KDM4E 1691/4885
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 LMNA 2309/4885TSHR 196/4885KDM4E 1710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.