Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.53 |
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | WNT1 | P04628 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13356455 | 0.88 | ACHE (0.59) | CYP1A2CYP3A4CYP2D6CLK4KDR | |
| SCHEMBL1256254 | 0.82 | KDR (0.57) | CYP1A2CYP3A4CYP2D6CLK4KDR | |
| SCHEMBL21064292 | 0.82 | KDR (0.55) | CYP1A2CYP3A4CYP2D6CLK4KDR | |
| Hydrochloric Acid SCHEMBL1257055 | 0.81 | KDR (0.56) | CYP1A2CYP3A4CYP2D6CLK4KDR | |
| SCHEMBL15394542 | 0.80 | KDR (0.57) | CYP1A2CYP3A4CYP2D6CLK4KDR | |
| SCHEMBL3249454 | 0.80 | KDR (0.57) | CYP1A2CYP3A4CYP2D6KDRLMNA | |
| SCHEMBL14732144 | 0.79 | KDR (0.51) | CYP1A2CYP3A4CYP2D6CLK4KDR | |
| SCHEMBL12978212 | 0.77 | SMN1; SMN2 (0.53) | LMNAMEN1KMT2A | |
| SCHEMBL1944938 | 0.77 | FYN (0.59) | KDRFYN | |
| SCHEMBL1256249 | 0.77 | KDR (0.54) | KDRFYNATRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |