Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119485 | 0.91 | PIK3CA (0.48) | PIK3CAHSD17B10CHRNA7BRD4GRM5 | |
| SCHEMBL3265059 | 0.90 | PIK3CA (0.43) | PIK3CAHSD17B10CHRNA7BRD4GRM5 | |
| SCHEMBL3121821 | 0.89 | PIK3CA (0.44) | PIK3CAHSD17B10CHRNA7GRM5CHRNA1 | |
| SCHEMBL3120379 | 0.85 | PIK3CA (0.41) | PIK3CAHSD17B10CHRNA7GRM5CHRNA1 | |
| SCHEMBL3116360 | 0.84 | GRM5 (0.50) | PIK3CAHSD17B10GRM5KDM4EALDH1A1 | |
| SCHEMBL3425682 | 0.79 | PIK3CA (0.61) | PIK3CAIKBKBKDM4EALDH1A1GAA | |
| SCHEMBL3268335 | 0.78 | PIK3CA (0.42) | PIK3CABRD4IKBKBKDM4EALDH1A1 | |
| SCHEMBL3247973 | 0.75 | PIK3CA (0.47) | PIK3CAHSD17B10IKBKBKDM4EALDH1A1 | |
| SCHEMBL3243835 | 0.73 | PTGS2 (0.36) | PIK3CABRD4GRM5PIK3CDPIK3CB | |
| SCHEMBL3124602 | 0.71 | HSD17B10 (0.51) | PIK3CAHSD17B10CHRNA7BRD4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001126-A1 | THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-01-07 | — | — | WO | disclosed |