Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995859 | 0.88 | PKM (0.78) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3005539 | 0.87 | PKM (0.65) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3115427 | 0.86 | ALDH1A1 (0.57) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3250826 | 0.80 | ALDH1A1 (0.58) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3006646 | 0.80 | NPSR1 (0.57) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL2997990 | 0.79 | ALDH1A1 (0.62) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3248337 | 0.79 | ALDH1A1 (0.75) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3002457 | 0.78 | PKM (0.57) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3004842 | 0.77 | PKM (0.62) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3003897 | 0.76 | ALDH1A1 (0.52) | MAPTPKMALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |