Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242758 | 0.91 | HRH3 (0.55) | HRH3MTNR1AMTNR1B | |
| SCHEMBL3242779 | 0.91 | HRH3 (0.55) | HRH3MTNR1AMTNR1B | |
| SCHEMBL3243916 | 0.90 | HRH3 (0.54) | HRH3CHRNA7MTNR1AMTNR1BHSD11B1 | |
| SCHEMBL3238698 | 0.90 | HRH3 (0.61) | HRH3MTNR1AMTNR1B | |
| SCHEMBL3242788 | 0.89 | HRH3 (0.53) | HRH3CHRNA7MTNR1AMTNR1BHSD11B1 | |
| SCHEMBL3238711 | 0.89 | HRH3 (0.53) | HRH3CHRNA7MTNR1AMTNR1BHSD11B1 | |
| SCHEMBL3238692 | 0.89 | HRH3 (0.53) | HRH3CHRNA7MTNR1AMTNR1B | |
| SCHEMBL3239247 | 0.89 | HRH3 (0.60) | HRH3CHRNA7 | |
| SCHEMBL3239367 | 0.89 | HRH3 (0.60) | HRH3CHRNA7 | |
| SCHEMBL3248240 | 0.88 | HRH3 (0.56) | HRH3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069331-B1 | 1H-INDOL-6-YL-PIPERAZIN-1-YL-METHANONE-DERIVATIVES FOR USE AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | disclosed |
| CN-101490039-A | 1H-indol-6-yl-piperazin-1-yl-methanone-derivatives for use as H3 receptor modulators | HOFFMANN LA ROCHE (CH) | 2009-07-22 | — | — | CN | disclosed |
| EP-2069331-A1 | 1H-INDOL-6-YL-PIPERAZIN-1-YL-METHANONE-DERIVATIVES FOR USE AS H3 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| US-7514433-B2 | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-04-07 | — | — | US | disclosed |
| WO-2008015125-A1 | 1H-INDOL-6-YL-PIPERAZIN-1-YL-METHANONE-DERIVATIVES FOR USE AS H3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-07 | — | — | WO | disclosed |
| US-20080032976-A1 | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032976-A1 | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives | HTR6, HTR1A, HRH4 | HRH3 5/4885CHRNA7 141/4885MTNR1A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.