Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.56 |
| ▸ | CCNK | O75909 | 6/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CCNH | P51946 | 2/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243908 | 0.88 | HRH3 (0.58) | HRH3CHRNA7 | |
| SCHEMBL3240701 | 0.88 | HRH3 (0.57) | HRH3CHRNA7GPR183 | |
| SCHEMBL3239367 | 0.87 | HRH3 (0.60) | HRH3CHRNA7 | |
| SCHEMBL27746330 | 0.84 | HRH3 (0.56) | HRH3CHRNA7 | |
| SCHEMBL3247741 | 0.84 | HRH3 (0.57) | HRH3 | |
| SCHEMBL3244945 | 0.83 | HRH3 (0.57) | HRH3CHRNA7 | |
| SCHEMBL3245572 | 0.83 | HRH3 (0.57) | HRH3CHRNA7 | |
| SCHEMBL3249663 | 0.83 | KDM4E (0.57) | HRH3CHRNA7 | |
| SCHEMBL3242758 | 0.83 | HRH3 (0.55) | HRH3 | |
| SCHEMBL3242779 | 0.83 | HRH3 (0.55) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069331-B1 | 1H-INDOL-6-YL-PIPERAZIN-1-YL-METHANONE-DERIVATIVES FOR USE AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | disclosed |
| EP-2069331-A1 | 1H-INDOL-6-YL-PIPERAZIN-1-YL-METHANONE-DERIVATIVES FOR USE AS H3 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| US-7514433-B2 | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20080032976-A1 | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-07 | — | — | US | disclosed |
| WO-2008015125-A1 | 1H-INDOL-6-YL-PIPERAZIN-1-YL-METHANONE-DERIVATIVES FOR USE AS H3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032976-A1 | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives | HTR6, HTR1A, HRH4 | HRH3 5/4885CCNK 1487/4885CDK12 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.