Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 10/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247916 | 0.87 | LTA4H (0.44) | RAB9ANPC1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3241858 | 0.79 | ELOVL1 (0.49) | SYKCYP3A4CYP2D6CYP2C9ATM | |
| SCHEMBL3249134 | 0.77 | HRH1 (0.42) | CYP3A4CYP2D6CYP2C9OXTR | |
| SCHEMBL6792817 | 0.75 | HRH1 (0.50) | SYKCYP3A4CYP2D6CYP2C9ALDH1A1 | |
| SCHEMBL3241892 | 0.75 | SMN1; SMN2 (0.40) | CYP3A4CYP2D6CYP2C9ALDH1A1ATM | |
| SCHEMBL18163283 | 0.75 | TDP1 (0.58) | RAB9ANPC1SYKAURKBINCENP | |
| SCHEMBL22645588 | 0.75 | TDP1 (0.58) | RAB9ANPC1SYKAURKBINCENP | |
| SCHEMBL3237662 | 0.73 | SYK (0.54) | RAB9ANPC1SYKAURKBINCENP | |
| SCHEMBL6859512 | 0.72 | HRH1 (0.55) | RAB9ANPC1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1422493 | 0.72 | MKNK1 (0.59) | CLK4OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |