Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243566 | 0.87 | KDM4E (0.51) | SMN1; SMN2KDM4EALDH1A1CDK8CD274 | |
| SCHEMBL3241858 | 0.83 | ELOVL1 (0.49) | KDM4EELOVL1CD274HRH1CYP3A4 | |
| SCHEMBL3244438 | 0.77 | CYP1A2 (0.52) | ALDH1A1CDK8AXLCYP1A2CYP2C19 | |
| SCHEMBL3247916 | 0.75 | LTA4H (0.44) | SMN1; SMN2ELOVL1HRH1CYP3A4CYP2D6 | |
| SCHEMBL3244498 | 0.75 | RAB9A (0.49) | ALDH1A1CYP3A4CYP2D6CYP2C9ATM | |
| SCHEMBL16180061 | 0.73 | HSD17B1 (0.60) | CDK8TRIM24TRIM33CA12CA1 | |
| SCHEMBL3249134 | 0.72 | HRH1 (0.42) | SMN1; SMN2ELOVL1CD274HRH1CA12 | |
| SCHEMBL3242889 | 0.72 | KDM4E (0.47) | KDM4ECD274ATM | |
| SCHEMBL5665266 | 0.71 | TLR4 (0.53) | SMN1; SMN2KDM4EALDH1A1CA12CA1 | |
| SCHEMBL6792817 | 0.71 | HRH1 (0.50) | SMN1; SMN2ALDH1A1HRH1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |