Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.60 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.60 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | HTR2C | P28335 | 6/20 | 0.51 |
| ▸ | HTR7 | P34969 | 6/20 | 0.51 |
| ▸ | HTR2B | P41595 | 6/20 | 0.51 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | DRD1 | P21728 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | TDP2 | O95551 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | RAD52 | P43351 | 2/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3253192 | 0.99 | KCNN2 (0.61) | KCNN2KCNN3KCNN1HTR2AHTR2C | |
| SCHEMBL3250383 | 0.97 | KCNN2 (0.64) | KCNN2KCNN3KCNN1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL3248244 | 0.96 | KCNN2 (0.65) | KCNN2KCNN3KCNN1HTR2AHTR2C | |
| SCHEMBL4413729 | 0.84 | LMNA (0.60) | KCNN2KCNN3KCNN1DRD1KDM4E | |
| SCHEMBL2112127 | 0.84 | LMNA (0.60) | KCNN2KCNN3KCNN1DRD1KDM4E | |
| Hydrochloric Acid SCHEMBL10746848 | 0.83 | LMNA (0.58) | KCNN2KCNN3KCNN1DRD1KDM4E | |
| Hydrochloric Acid SCHEMBL11099161 | 0.83 | LMNA (0.58) | KCNN2KCNN3KCNN1DRD1KDM4E | |
| SCHEMBL6130855 | 0.79 | HTR7 (0.52) | HTR2AHTR2CHTR7HTR2BHTR1A | |
| SCHEMBL6130831 | 0.79 | HTR7 (0.52) | HTR2AHTR2CHTR7HTR2BHTR1A | |
| SCHEMBL3253219 | 0.78 | KCNN2 (0.94) | KCNN2KCNN3KCNN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998775-B1 | BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS | UNIV LIEGE (BE) | 2010-05-19 | — | — | EP | claimed |