Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.51 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.51 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112127 | 1.00 | LMNA (0.60) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL10746848 | 0.99 | LMNA (0.58) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL11099161 | 0.99 | LMNA (0.58) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| SCHEMBL29924522 | 0.85 | LMNA (0.81) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| SCHEMBL29748937 | 0.85 | LMNA (0.81) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| SCHEMBL29837028 | 0.85 | LMNA (0.81) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| SCHEMBL2112478 | 0.85 | LMNA (0.81) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL14691397 | 0.84 | LMNA (0.79) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| SCHEMBL3244548 | 0.84 | KCNN2 (0.60) | LMNAKDM4EALDH1A1HSD17B10MAPK1 | |
| SCHEMBL3250383 | 0.84 | KCNN2 (0.64) | LMNAKDM4EALDH1A1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380573-B1 | Isoquinolines and preparation thereof | AVERA PHARMACEUTICALS INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-0971898-B1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | AVERA PHARMACEUTICALS INC (US) | 2005-05-11 | — | — | EP | disclosed |
| EP-1526130-A1 | Substituted isoquinolines as ultra short acting neuromuscular blockers | Avera Pharmaceuticals, Inc. (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1380573-A2 | Isoquinolines and preparation thereof | Avera Pharmaceuticals, Inc. (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-0975599-B1 | SUBTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | AVERA PHARMACEUTICALS INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6187789-B1 | MUSCLE RELAXANTS FOR EMERGENCY INTUBATION AND SURGERY | GLAXO WELLCOME INC. | 2001-02-13 | — | — | US | disclosed |
| US-6177445-B1 | MUSCLE RELAXANTS | GLAXO WELLCOME INC. | 2001-01-23 | — | — | US | disclosed |