Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 4/20 | 0.57 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244355 | 0.88 | ROCK2 (0.53) | CITROCK2ROCK1F3DGAT2 | |
| SCHEMBL3129372 | 0.88 | ROCK2 (0.47) | CITTNIKROCK2ROCK1CYP2D6 | |
| SCHEMBL3130579 | 0.88 | JAK3 (0.47) | CITTNIKROCK2ROCK1 | |
| SCHEMBL3243730 | 0.85 | ROCK2 (0.58) | CITTNIKROCK2ROCK1BRAF | |
| SCHEMBL3248895 | 0.83 | ROCK2 (0.55) | CITTNIKROCK2ROCK1BRAF | |
| SCHEMBL3240812 | 0.82 | ROCK2 (0.51) | ROCK2ROCK1F3 | |
| SCHEMBL13391340 | 0.80 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL3245171 | 0.77 | ROCK2 (0.69) | ROCK2ROCK1 | |
| SCHEMBL1647246 | 0.74 | PRKACA (0.65) | CITTNIKROCK2ROCK1CYP2D6 | |
| SCHEMBL12779735 | 0.74 | ROCK2 (0.70) | CITTNIKROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |