Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.57 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247175 | 0.91 | ROCK2 (0.57) | ROCK2ROCK1CDC42BPANPC1RAB9A | |
| SCHEMBL3252352 | 0.90 | ROCK2 (0.64) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL13391213 | 0.88 | ROCK2 (0.71) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3255470 | 0.87 | ROCK2 (0.74) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL21979537 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL20661005 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL20661002 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL20661008 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL20661188 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL3248686 | 0.79 | ROCK2 (0.64) | ROCK2ROCK1CDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |