Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.57 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13391161 | 0.88 | ROCK2 (0.62) | ROCK2CDC42BPAROCK1LCKSRC | |
| SCHEMBL3129042 | 0.88 | ROCK2 (0.60) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3247404 | 0.87 | ROCK2 (0.74) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3246921 | 0.87 | ROCK2 (0.54) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL13391129 | 0.84 | ROCK2 (0.67) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3124049 | 0.82 | ROCK2 (0.60) | ROCK2CDC42BPAROCK1KDR | |
| SCHEMBL3248676 | 0.81 | ROCK2 (0.58) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3248596 | 0.81 | ROCK2 (0.53) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3252386 | 0.81 | ROCK2 (0.57) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL3251643 | 0.80 | ROCK2 (0.45) | ROCK2CDC42BPAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |