SCHEMBL3246472

SCHEMBL3246472

Nc1cc(Cc2cccc(Cl)c2F)cc2c(=O)c(OC(=O)O)cn(CCO)c12

nearest known ligand 0.39

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 1/20 0.39
CFD P00746 1/20 0.31
MRGPRX4 Q96LA9 1/20 0.31
SLC22A12 Q96S37 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3232649 0.89 METTL3 (0.46) METTL3CFDMAPT
SCHEMBL1046140 0.88 METTL3 (0.44) METTL3CFDMAPT
SCHEMBL3246482 0.88 METTL3 (0.38) METTL3MRGPRX4
SCHEMBL3245181 0.88 METTL3 (0.40) METTL3CFDSLC22A12MAPT
SCHEMBL3241137 0.87 METTL3 (0.40) METTL3MAPT
SCHEMBL3234775 0.87 METTL3 (0.40) METTL3CFDMRGPRX4MAPT
SCHEMBL3243220 0.87 METTL3 (0.38) METTL3MAPT
SCHEMBL3240311 0.86 METTL3 (0.42) METTL3CFD
SCHEMBL3246516 0.86 METTL3 (0.38) METTL3CFD
SCHEMBL3247049 0.86 METTL3 (0.39) METTL3CFD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1564210-B9 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS JAPAN TOBACCO INC (JP) 2010-03-31 EP claimed
EP-1564210-B1 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS JAPAN TOBACCO INC (JP) 2009-09-16 EP claimed