SCHEMBL3246486

SCHEMBL3246486

Fc1[c]ccc(CNc2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.46
PPARA Q07869 4/20 0.43
FFAR4 Q5NUL3 1/20 0.41
MAPT P10636 1/20 0.39
CACNA1B Q00975 3/20 0.39
CYP3A4 P08684 1/20 0.38
CYP2C19 P33261 1/20 0.38
BRD4 O60885 1/20 0.38
MTOR P42345 2/20 0.38
CLK1 P49759 1/20 0.37
DYRK1A Q13627 1/20 0.37
ADRA2A P08913 1/20 0.36
CACNA1H O95180 1/20 0.36
RHOC P08134 1/20 0.36
RHOA P61586 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3246732 0.84 FFAR1 (0.45) FFAR1PPARAFFAR4MAPTCACNA1B
SCHEMBL3249812 0.81 MEN1 (0.45) FFAR1MAPTCYP2C19RHOCRHOA
SCHEMBL3246798 0.79 FFAR1 (0.55) FFAR1PPARAFFAR4MAPTCACNA1B
SCHEMBL3245006 0.77 RHOC (0.44) FFAR1PPARAFFAR4MAPTCYP3A4
SCHEMBL7345712 0.76 FFAR1 (0.68) FFAR1PPARAFFAR4MAPTCACNA1B
SCHEMBL3249639 0.75 MAPT (0.43) FFAR1MAPTCYP3A4CYP2C19
SCHEMBL3240177 0.74 NOS1 (0.41) FFAR1PPARAFFAR4MAPTCACNA1B
SCHEMBL5544782 0.72 FFAR1 (0.55) FFAR1PPARACACNA1BADRA2ACACNA1H
SCHEMBL7102889 0.72 FFAR1 (0.62) FFAR1FFAR4MAPTCACNA1B
SCHEMBL6557440 0.69 FFAR1 (0.63) FFAR1PPARAMAPTCACNA1BMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2185149-A1 USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED H. Lundbeck A/S (DK) 2010-05-19 EP claimed
WO-2009015667-A1 USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED H. LUNDBECK A/S (DK) 2009-02-05 WO claimed
WO-2024054811-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 WO disclosed
EP-2185149-A1 USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED H. Lundbeck A/S (DK) 2010-05-19 EP disclosed
WO-2009015667-A1 USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED H. LUNDBECK A/S (DK) 2009-02-05 WO disclosed