Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245006 | 0.84 | RHOC (0.44) | CYP3A4CYP2C19PPARAMAPTTP53 | |
| SCHEMBL856260 | 0.79 | CA1 (0.56) | NOS1CACNA1BCA1CA2CA9 | |
| SCHEMBL3251941 | 0.79 | KMT2A (0.43) | NOS1CYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL3246732 | 0.76 | FFAR1 (0.45) | CACNA1BCYP3A4CYP2C19PPARAMAPT | |
| SCHEMBL3246486 | 0.74 | FFAR1 (0.46) | CACNA1BCYP3A4CYP2C19PPARAMAPT | |
| SCHEMBL10449130 | 0.71 | APP (0.46) | CYP3A4ALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL26268446 | 0.70 | RORC (0.48) | CACNA1BCYP3A4CYP2C19CA1CA2 | |
| SCHEMBL3246798 | 0.69 | FFAR1 (0.55) | CACNA1BPPARACA1CA2ALDH1A1 | |
| SCHEMBL3104491 | 0.69 | KCNQ2 (0.52) | CYP3A4CYP2C19PPARAALDH1A1MAPT | |
| SCHEMBL11671967 | 0.68 | KIF11 (0.59) | KDM1AALDH1A1MAPTKIF11MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185149-A1 | USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED | H. Lundbeck A/S (DK) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009015667-A1 | USE OF KNCQ POTASSIUM CHANNEL OPENERS FOR REDUCING SYMPTOMS OF OR TREATING DISORDERS OR CONDITIONS WHEREIN THE DOPAMINERGIC SYSTEM IS DISRUPTED | H. LUNDBECK A/S (DK) | 2009-02-05 | — | — | WO | disclosed |