Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.39 |
| ▸ | FNTB | P49356 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267887 | 0.94 | MAPK1 (0.45) | MAPK1KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL3130951 | 0.85 | ESR1 (0.43) | MAPK1KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL3246489 | 0.85 | CYP11B2 (0.36) | FNTAFNTBKDM4ELMNASMN1; SMN2 | |
| SCHEMBL13521719 | 0.84 | TSHR (0.46) | MAPK1LMNAHTTGAATSHR | |
| SCHEMBL3118590 | 0.83 | ESR2 (0.45) | MAPK1KDM4EHTTTSHRCYP11B2 | |
| SCHEMBL3241068 | 0.82 | CYP11B2 (0.41) | CYP11B2 | |
| SCHEMBL3127545 | 0.81 | MAPK1 (0.41) | MAPK1KDM4EHTTTSHRCYP11B2 | |
| SCHEMBL3247392 | 0.81 | HSD17B3 (0.43) | CYP11B2GRIN2BGRIN1 | |
| SCHEMBL3236789 | 0.80 | GAA (0.55) | MAPK1KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL3122131 | 0.78 | MAPK1 (0.43) | MAPK1TSHRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |