Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837508 | 0.92 | PTGS2 (0.84) | PTGS2PTGS1 | |
| SCHEMBL5616866 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3247750 | 0.78 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7836982 | 0.78 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3245733 | 0.77 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL7835519 | 0.74 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL5261561 | 0.72 | KDM4E (0.59) | PTGS2PTGS1 | |
| SCHEMBL7220519 | 0.72 | KDM4E (0.59) | PTGS2PTGS1 | |
| SCHEMBL5345880 | 0.71 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL7714593 | 0.71 | PTGS2 (0.55) | PTGS2CHEK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390026-B1 | TREATMENT OF HPV CAUSED DISEASES | CORNELL RES FOUNDATION INC (US) | 2010-05-05 | — | — | EP | claimed |
| EP-0802917-B1 | ARYL SUBSTITUTED 5,5 FUSED AROMATIC NITROGEN COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | MERCK FROSST CANADA INC (CA) | 2001-11-07 | — | — | EP | claimed |
| EP-0802917-A1 | ARYL SUBSTITUTED 5,5 FUSED AROMATIC NITROGEN COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | MERCK FROSST CANADA INC. (CA) | 1997-10-29 | — | — | EP | claimed |
| US-5552422-A | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1996-09-03 | — | — | US | claimed |
| WO-1996021667-A1 | ARYL SUBSTITUTED 5,5 FUSED AROMATIC NITROGEN COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | MERCK FROSST CANADA INC. (CA) | 1996-07-18 | — | — | WO | claimed |
| CN-117877625-A | Virtual screening method for inhibitor MPB with human cyclooxygenase 2 as target and inhibitor thereof | 重庆医科大学国际体外诊断研究院 | 2024-04-12 | — | — | CN | disclosed |
| EP-1039914-A4 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RES FOUNDATION INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-7041694-B1 | Cyclooxygenase-2 inhibition | CORNELL RESEARCH FOUNDATION, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1109553-A4 | TREATING INFLAMMATORY DISEASES OF THE HEAD AND NECK WITH CYCLOOXYGENASE-2 INHIBITORS | CORNELL RES FOUNDATION INC (US) | 2003-12-10 | — | — | EP | disclosed |
| US-6486203-B1 | Treating inflammatory diseases of the head and neck with cyclooxygenase-2 inhibitors | CORNELL RESEARCH FOUNDATION, INC. | 2002-11-26 | — | — | US | disclosed |
| US-6403630-B1 | ADMINISTERING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR ALONE OR IN COMBINATION WITH HERCEPTIN? ANTIBODY; USED TO TREAT BREAST CANCER | CORNELL RESEARCH FOUNDATION, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-0802917-B1 | ARYL SUBSTITUTED 5,5 FUSED AROMATIC NITROGEN COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | MERCK FROSST CANADA INC (CA) | 2001-11-07 | — | — | EP | disclosed |
| EP-1109553-A1 | TREATING INFLAMMATORY DISEASES OF THE HEAD AND NECK WITH CYCLOOXYGENASE-2 INHIBITORS | CORNELL RESEARCH FOUNDATION, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| EP-1039914-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-2000013685-A1 | TREATING INFLAMMATORY DISEASES OF THE HEAD AND NECK WITH CYCLOOXYGENASE-2 INHIBITORS | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-03-16 | — | — | WO | disclosed |
| WO-1999030721-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| US-5552422-A | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1996-09-03 | — | — | US | disclosed |