Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243303 | 0.91 | TP53 (0.38) | TP53LMNAMAPTALDH1A1HTR6 | |
| SCHEMBL3235211 | 0.89 | TP53 (0.36) | TP53LMNAMAPTALDH1A1HTR6 | |
| SCHEMBL3242661 | 0.89 | TP53 (0.36) | TP53LMNAMAPTALDH1A1RXFP1 | |
| SCHEMBL3239841 | 0.89 | TP53 (0.37) | TP53LMNAMAPTALDH1A1HTR6 | |
| SCHEMBL3237627 | 0.89 | TP53 (0.37) | TP53LMNAMAPTALDH1A1RXFP1 | |
| SCHEMBL1045361 | 0.88 | LMNA (0.43) | TP53LMNAMAPTALDH1A1PDE4A | |
| SCHEMBL3241776 | 0.88 | ALDH1A1 (0.36) | TP53LMNAMAPTALDH1A1HTR6 | |
| SCHEMBL3246985 | 0.88 | TP53 (0.37) | TP53LMNAMAPTALDH1A1RXFP1 | |
| SCHEMBL3245273 | 0.85 | MAPT (0.41) | TP53LMNAMAPTALDH1A1RXFP1 | |
| SCHEMBL3243355 | 0.84 | ALDH1A1 (0.40) | TP53LMNAMAPTALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1564210-B9 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2010-03-31 | — | — | EP | claimed |
| EP-1564210-B1 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2009-09-16 | — | — | EP | claimed |