Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 20/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215341 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL6352647 | 0.82 | PTGS2 (0.80) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL3243184 | 0.81 | PTGS2 (0.82) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL3249718 | 0.81 | PTGS2 (0.95) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL212658 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL213150 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL6339240 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL7789562 | 0.81 | PTGS2 (0.78) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL6339195 | 0.81 | PTGS2 (0.90) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL5608566 | 0.79 | PTGS2 (0.79) | PTGS2PTGS1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390026-B1 | TREATMENT OF HPV CAUSED DISEASES | CORNELL RES FOUNDATION INC (US) | 2010-05-05 | — | — | EP | claimed |
| EP-1146789-B1 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/NEU | CORNELL RES FOUNDATION INC (US) | 2009-03-18 | — | — | EP | claimed |
| EP-1146789-B1 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/NEU | CORNELL RES FOUNDATION INC (US) | 2009-03-18 | — | — | EP | disclosed |
| US-7041694-B1 | Cyclooxygenase-2 inhibition | CORNELL RESEARCH FOUNDATION, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| US-6486203-B1 | Treating inflammatory diseases of the head and neck with cyclooxygenase-2 inhibitors | CORNELL RESEARCH FOUNDATION, INC. | 2002-11-26 | — | — | US | disclosed |
| US-6403630-B1 | ADMINISTERING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR ALONE OR IN COMBINATION WITH HERCEPTIN? ANTIBODY; USED TO TREAT BREAST CANCER | CORNELL RESEARCH FOUNDATION, INC. | 2002-06-11 | — | — | US | disclosed |
| US-5466823-A | Antiinflammatory agents; FDA Orange book listed patent for Celebrex | G.D. SEARLE & CO. (US) | 1995-11-14 | — | — | US | disclosed |