Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | PNMT | P11086 | 4/20 | 0.46 |
| ▸ | CD44 | P16070 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17585071 | 0.89 | ASIC3 (0.55) | ASIC3DRD2DRD3PNMTCD44 | |
| SCHEMBL4565700 | 0.86 | ASIC3 (0.55) | ASIC3DRD2DRD3PNMTCD44 | |
| Hydrochloric Acid SCHEMBL1265678 | 0.84 | ASIC3 (0.53) | ASIC3DRD2DRD3PNMTCD44 | |
| SCHEMBL18717400 | 0.83 | ASIC3 (0.51) | ASIC3DRD2DRD3PNMTCD44 | |
| SCHEMBL3243076 | 0.83 | ASIC3 (0.51) | ASIC3DRD2DRD3PNMTCD44 | |
| SCHEMBL3055999 | 0.83 | ASIC3 (0.51) | ASIC3DRD2DRD3PNMTCD44 | |
| SCHEMBL26141680 | 0.82 | PNMT (0.55) | DRD2DRD3PNMTCD44MAOB | |
| Hydrochloric Acid SCHEMBL23706229 | 0.81 | PNMT (0.53) | DRD2DRD3PNMTCD44MAOB | |
| Hydrochloric Acid SCHEMBL30041859 | 0.81 | PNMT (0.53) | DRD2DRD3PNMTCD44MAOB | |
| SCHEMBL20803992 | 0.80 | ASIC3 (0.49) | ASIC3DRD2DRD3PNMTCD44 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |