Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3124049 | 0.93 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPAKDRKIT | |
| SCHEMBL13390977 | 0.92 | ROCK2 (0.57) | ROCK2ROCK1CDC42BPAKDRFLT3 | |
| SCHEMBL3246515 | 0.92 | ROCK2 (0.57) | ROCK2ROCK1CDC42BPAKDR | |
| SCHEMBL3248059 | 0.88 | ROCK2 (0.57) | ROCK2ROCK1CDC42BPAKDRKIT | |
| SCHEMBL3249575 | 0.88 | ROCK2 (0.43) | ROCK2ROCK1 | |
| SCHEMBL3248596 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1CDC42BPAAKT1 | |
| SCHEMBL3243986 | 0.84 | ROCK2 (0.66) | ROCK2ROCK1CDC42BPAKDRFLT3 | |
| SCHEMBL3240774 | 0.84 | ROCK2 (0.62) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3238586 | 0.84 | ROCK2 (0.52) | ROCK2ROCK1CDC42BPAAKT1 | |
| SCHEMBL3244463 | 0.83 | ROCK2 (0.42) | ROCK2ROCK1CDC42BPAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |